Biological activities and modes of action of 9-α-d-arabinofuranosyladenine and 9-α-d-arabinofuranosyl-8-azaadenine
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Differences in Metabolism and Cytotoxicity between 9-ß-o Arabinofuranosyladenine and 9-/?-D-Arabinofuranosyl-2- fluoroadenine in Human Leukemic Lymphoblasts1
We compared the effects of 9-/?-o-arabinofuranosyladenine (ara-A) and its 2-fluoro derivative (F-ara-A) on DMA synthesis and viability in human leukemic lymphoblasts (CCRF-CEM). The relative DNA content and cloning capacity of the cells were determined by flow cytometry and growth in methylcellulose, respectively. Incubation with either 1 /IM ara-A in the presence of 2'-deoxycoformycin, a poten...
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Leung, Hazel Barner (University of Pennsylvania School of Medicine, Philadelphia), Alice McGovern Doering, and Seymour S. Cohen. Effect of 9-beta-d-arabinofuranosyladenine on polymer synthesis in a polyauxotrophic strain of Escherichia coli. J. Bacteriol. 92:558-564. 1966.-Adenine-requiring mutants have been obtained from Escherichia coli strain 15 TAU, which also needs thymine, arginine, and u...
متن کاملSequence-specific inhibition of DNA strand elongation by incorporation of 9-beta-D-arabinofuranosyladenine.
9-beta-D-Arabinofuranosyladenine (ara-A) is an inhibitor of DNA replication with antitumor and antiviral activity. The molecular basis for this inhibitory effect has remained unclear. The present work has examined the effects of 9-beta-D-arabinofuranosyladenine-triphosphate on DNA polymerase-beta. These studies were performed on different M13 phage DNA templates. The findings demonstrate that 9...
متن کامل9-beta-D-arabinofuranosyladenine 5'-phosphate metabolism and excretion in humans.
9-beta-D-Arabinofuranosyladenine (ara-A) was converted chemically to the 9-beta-D-arabinofuranosyladenine 5'-phosphate (ara-A-5'-P) and administered i.v. to four cancer patients in seven experiments. Urinary excretion and plasma levels of radioactivity were monitored for 24 hr in each case. Radioactivity present as unchanged ara-A-5'-P, ara-A, and the deamination product of ara-A, 9-beta-D-arab...
متن کاملInsulinotropic action of α-d-glucose pentaacetate: functional aspects.
The functional determinants of the insulinotropic action of α-d-glucose pentaacetate were investigated in rat pancreatic islets. The ester mimicked the effect of nutrient secretagogues by recruiting individual B cells into an active secretory state, stimulating proinsulin biosynthesis, inhibiting86Rb outflow, and augmenting45Ca efflux from prelabeled islets. The secretory response to the ester ...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 1981
ISSN: 0006-2952
DOI: 10.1016/0006-2952(81)90106-4